Immunohistochemical and molecular genetic analyses of multiple sporadic gastrointestinal stromal tumors

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Sep 15, 2010 (publication date) through Jan 24, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Sep 15, 2010; 2(9): 364-368
Published online Sep 15, 2010. doi: 10.4251/wjgo.v2.i9.364

Table 3 Discrimination of the multiple gastrointestinal stromal tumor in adult[6-10,12]

	Clinical features	Mutation	Hyperplasia of ICC	Family history	Muscularis propria involvement
Sporadic GIST	(-)	(+) Somatic mutation	(-)	(-)	(+)
Familial GIST	(+) Skin pigmentation	(+) Germline mutation	(+) Diffuse	(+)	(+)
Neurofibromatosis type 1 associated GIST	(+) Skin nodule and pigmentation	(-) rare	(+) Focal or mild	(+)	(+)
Metastatic disease	^a	^a	^a	^a	(-)

^aSame or similar to primary tumor. ICC: Interstitial cells of Cajal; GIST: Gastrointestinal stromal tumor.

Citation: Hiraki M, Kitajima Y, Ohtsuka T, Kai K, Miyake S, Koga Y, Mori D, Noshiro H, Tokunaga O, Miyazaki K. Immunohistochemical and molecular genetic analyses of multiple sporadic gastrointestinal stromal tumors. World J Gastrointest Oncol 2010; 2(9): 364-368
URL: https://www.wjgnet.com/1948-5204/full/v2/i9/364.htm
DOI: https://dx.doi.org/10.4251/wjgo.v2.i9.364