Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan

Table 5 Distribution of Caveolin-1 G14713A and T29107A genotypes and colorectal cancer after stratification by smoking habit

	Overall			Never smokers			Ever smokers
SNP/Genotype	Controls	Cases	Adjusteda	Controls	Cases	Adjustedb	Controls	Cases	Adjustedb
	n (%)	n (%)	OR (95% CI)	n (%)	n (%)	OR (95% CI)	n (%)	n (%)	OR (95% CI)
G14713A (rs3807987) GG AG AA	234 (64.6)  96 (26.5)  32 ( 8.8)	135 (37.3) 165 (45.6) 62 (17.1)	1.00 (Ref.) 2.98 (2.14-4.14) 3.36 (2.09-5.41)	171 (63.1) 75 (27.7)  25 (9.2)	107 (38.5) 124 (44.6) 47 (16.9)	1.00 (Ref.) 2.64 (1.81-3.84) 3.00 (1.75-5.17)	63 (69.2) 21 (23.1) 7 (7.7)	28 (33.3) 41 (48.8) 15 (17.9)	1.00 (Ref.) 4.39 (2.21-8.75) 4.82 (1.77-13.13)
T29107A (rs7804372) TT AT AA	179 (49.5) 120 (33.1) 63 (17.4)	216 (59.7) 117 (32.3) 29 (8.0)	1.00 (Ref.) 0.79 (0.57-1.11) 0.37 (0.23-0.58)	136 (50.2) 89 (32.8) 46 (17.0)	164 (59.0) 91 (32.7) 23 (8.3)	1.00 (Ref.) 0.84 (0.54-1.21) 0.40 (0.22-0.71)	43 (47.3) 52 (34.1) 17 (18.6)	52 (61.9) 26 (31.0) 6 (7.1)	1.00 (Ref.) 0.40 (0.22-0.76) 0.28 (0.21-0.79)

^aAdjusted for age, gender and smoking (pack-years); ^bAdjusted for age and gender; OR: Odds ratio; SNP: Single nucleotide polymorphism.