Hyperthermic intraperitoneal chemotherapy: Rationale and technique

Table 1 Common HIPEC regimens currently in use

Center/Country	HIPEC drug (s) and doses	HIPEC duration	Concomitant intravenous	EPIC	Indication
		(min)	chemotherapy
Washington hospital center/	Mitomycin C, 15 mg/m2	90	5-FU, 400 mg/m2	5-FU	Appendiceal, and
Washington, DC (USA)	Doxorubicin, 15 mg/m2		LV, 20 mg/m2	4 d	colorectal carcinomatosis
Washington hospital center/	Cisplatin, 50 mg/m2	90	5-FU, 400 mg/m2	Taxol	Gastric cancer, peritoneal
Washington, DC (USA)	Doxorubicin, 15 mg/m2		LV, 20 mg/m2	4 d	mesothelioma, ovarian
					cancer
Washington hospital center/	Oxaliplatin, 130 mg/m2	60	5-FU, 400 mg/m2	5-FU	Appendiceal, and
Washington, DC (USA)			LV, 20 mg/m2	4 d	colorectal carcinomatosis
Washington hospital center/	Melphalan, 50-70 mg/m2	60	No	No	Carcinomatosis with
Washington, DC (USA)					incomplete cytoreduction
Gustave roussy institute/	Oxaliplatin, 460 mg/m2	30	5-FU, 400 mg/m2	No	Colorectal carcinomatosis
Villejuif (France)			LV, 20 mg/m2
National cancer institute/	Mitomycin C, 35 mg/m2	90	No	No	Appendiceal, and
Amsterdam (Netherlands)					colorectal carcinomatosis
National cancer institute/	Cisplatin, 43 mg/L	90	No	No	Peritoneal mesothelioma,
Milan (Italy)	Doxorubicin ,15.25 mg/L				advanced ovarian cancer
National cancer institute/	Mitomycin C, 3.3mg/m2/L	90	No	No	Appendiceal, and
Milan (Italy)	Cisplatin, 25 mg/m2/L				colorectal carcinomatosis;
					advanced ovarian cancer;
					peritoneal mesothelioma
Centre hospitalo-universitaire	Mitomycin C,	90	No	No	Appendiceal, gastric and
lyon-sud/Lyon (France)	10 mg/mL of perfusate				colorectal carcinomatosis
Centre hospitalo-universitaire	Mitomycin C, 0.5 mg/kg	90	No	No	Peritoneal mesothelioma
lyon-sud/Lyon (France)	Cisplatin 0.7 mg/kg
Centre hospitalo-universitaire	Cisplatin, 20 mg/m2/L	90	No	No	Recurrent and
lyon-sud/Lyon (France)					chemoresistant stage III
					ovarian cancer
National cancer institute/	Cisplatin, 250 mg/m2	90	No	5-FU + Taxol	Peritoneal mesothelioma
Bethesda, MD (USA)				1 d

L: liter of perfusate; HIPEC: Hyperthermic intraperitoneal chemotherapy; EPIC: Early postoperative intraperitoneal chemotherapy.