Impact of SLC16A8 on tumor microenvironment and angiogenesis in colorectal cancer: New therapeutic target insights

doi:10.4251/wjgo.v17.i4.99188

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Apr 15, 2025 (publication date) through Mar 28, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2025; 17(4): 99188
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.99188

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Figure 8 Graphical abstract. Under hypoxic conditions, the metabolic pathways in tumor tissues change, and lactate production increases. The expression of SLC16A8 is upregulated, causing the extrusion of lactate from cells. This leads to an increase in the distribution of tumor microvessels, providing conditions for tumor metastasis. EndMT: Endothelial-mesenchymal transition.

Citation: Tian HP, Xiao ZX, Su BW, Li YX, Peng H, Meng CY. Impact of SLC16A8 on tumor microenvironment and angiogenesis in colorectal cancer: New therapeutic target insights. World J Gastrointest Oncol 2025; 17(4): 99188
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/99188.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.99188