Impact of SLC16A8 on tumor microenvironment and angiogenesis in colorectal cancer: New therapeutic target insights

doi:10.4251/wjgo.v17.i4.99188

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Apr 15, 2025 (publication date) through Mar 28, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2025; 17(4): 99188
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.99188

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Figure 5 SLC16A8 siRNA reverses the effects of hypoxia on cell metabolic reprogramming. A: SLC16A8 siRNA affects the expression of SLC16A8 in hypoxia treated cells; B: Effect of SLC16A8 siRNA on ECAR of hypoxia treated cells; C: SLC16A8 siRNA can affect the level of extracellular lactic acid after hypoxia treatment; D: SLC16A8 siRNA affects the expression of PKM2 and LDHA in hypoxia treated cells; E: Effect of SLC16A8 siRNA on glucose consumption in hypoxia treated cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. 2-DG: 2-deoxyglucose.

Citation: Tian HP, Xiao ZX, Su BW, Li YX, Peng H, Meng CY. Impact of SLC16A8 on tumor microenvironment and angiogenesis in colorectal cancer: New therapeutic target insights. World J Gastrointest Oncol 2025; 17(4): 99188
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/99188.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.99188