Impact of SLC16A8 on tumor microenvironment and angiogenesis in colorectal cancer: New therapeutic target insights

Figure 2 Effects of hypoxia on SLC16A8 expression and metabolic reprogramming of colorectal cancer cells. A: The expression level of SLC16A8 in colorectal cancer cell lines; B: The expression characteristics of SLC16A8 under hypoxia; C: The effect of hypoxia on the ECAR of RKO and LoVo; D: The effect of hypoxia on the extracellular lactate levels of RKO and LoVo; E: The effect of hypoxia on the expression of PKM2 and LDHA, the key proteins of metabolic reprogramming; F: The effect of hypoxia on glucose consumption in RKO and LoVo cells. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.