Snail family transcriptional repressor 1 radiosensitizes esophageal cancer via epithelial-mesenchymal transition signaling: From bioinformatics to integrated study

Figure 6 Schematic representation of the ionizing radiation-mediated regulation of radiosensitivity in esophageal cancer cells through Snail family transcriptional repressor 1. Ionizing radiation influences Snail family transcriptional repressor 1 by diminishing its recruitment at the deacetylation site within the CDH1 promoter region. This attenuation culminates in the upregulation of CDH1 expression, thereby promoting the epithelial-mesenchymal transition process within cells. Ultimately, these molecular events play a pivotal role in shaping the radiosensitivity of esophageal cancer cells. SNAI1: Snail family transcriptional repressor 1.