Snail family transcriptional repressor 1 radiosensitizes esophageal cancer via epithelial-mesenchymal transition signaling: From bioinformatics to integrated study

Figure 5 Snail family transcriptional repressor 1 regulates esophageal cancer cell radiosensitivity by epithelial-mesenchymal transition-related deacetylation. A: Gene set enrichment analysis of Snail family transcriptional repressor 1 (SNAI1) in esophageal cancer; B: Phenotypic changes in TE-1 and KYSE-30 cells upon SNAI1 knockdown; C: Changes in epithelial-mesenchymal transition (EMT) markers upon SNAI1 downregulation in TE-1 and KYSE-30 cells; D: Chromatin immunoprecipitation with subsequent E-cadherin PCR amplification gel electrophoresis; E: Western blot analysis of EMT marker expression in TE-1 and KYSE-30 cells under small interfering SNAI1 (siSNAI1), SNAI1-OE, and irradiation; F: Western blot analysis of EMT marker expression in TE-1 and KYSE-30 cells under siSNAI1, SAHA, and irradiation. NC: Negative control; siSNAI1: Small interfering Snail family transcriptional repressor 1.