Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells

Figure 4 Tetramethylpyrazine inhibits tumor growth in a xenograft mouse model. A: Tumor volumes were calculated in mice treated with different concentrations of tetramethylpyrazine (TMP; 0, 50, and 100 mg/kg body weight) for 30 days (n = 5 mice/group); B: Tumor weight was calculated in mice treated with different concentrations of TMP (0, 50, and 100 mg/kg body weight) for 30 days (n = 5 mice/group). ^aP < 0.05, ^bP < 0.01. TMP: Tetramethylpyrazine.