Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells

doi:10.4251/wjgo.v17.i4.104922

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Apr 15, 2025 (publication date) through Apr 21, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2025; 17(4): 104922
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.104922

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Figure 3 Caspases 3 and 9 cleavage induced by tetramethylpyrazine is inhibited by N-acetyl-L-cysteine and Z-VAD-FMK. Western blot analysis showed increased cleaved caspase 3 and caspase 9 expression in SW480 and HCT116 cells treated with tetramethylpyrazine with or without Z-VAD-FMK and N-acetyl-L-cysteine. TMP: Tetramethylpyrazine; NAC: N-acetyl-L-cysteine.

Citation: Hou YX, Ren W, He QQ, Huang LY, Gao TH, Li H. Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells. World J Gastrointest Oncol 2025; 17(4): 104922
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/104922.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.104922