Detecting plasma SHOX2, HOXA9, SEPTIN9, and RASSF1A methylation and circulating cancer cells for cholangiocarcinoma clinical diagnosis and monitoring

Figure 4 The receiver operating characteristic curves and resulting area under the curve values for patients with cholangiocarcinoma (n = 156) and early cholangiocarcinoma (n = 11). A: The receiver operating characteristic curves of complex methylation and carbohydrate antigen 19-9 (CA199) of the patients. area under the curve (AUC)-complex methylation = 0.828 (95%CI: 0.764-0.891), AUC-CA199 = 0.746 (95%CI: 0.666-0.826), AUC-complex methylation + CA199 = 0.851 (95%CI: 0.792-0.910); B and C: The AUC of the complex evaluation and CA199 for diagnosing early cholangiocarcinoma. AUC-complex methylation = 0.682 (95%CI: 0.654-0.710), AUC-CA199 = 0.542 (95%CI: 0.358-0.726). CA199: Carbohydrate antigen 19-9.