Oesophageal cancer-specific mortality risk and public health insurance: Prospective cohort study from China

Table 4 Association of every 10% insurance out-of-pocket ratio increase with esophagus cancer-specific death and all-cause death

Variables	Patients (n)	Events (n)	Rate	1Model A		2Model B		3Model C
				HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Overall mortality
Any type per 10% increase	2543	1438	13.46	0.972 (0.945-0.999)	0.045	0.943 (0.916-0.972)	< 0.001	0.955 (0.927-0.984)	0.002
Within URBMI per 10% increase	1871	1012	13.24	1.029 (0.988-1.071)	0.173	0.984 (0.941-1.029)	0.483	0.988 (0.945-1.034)	0.608
Within UEBMI per 10% increase	672	426	17.43	0.893 (0.832-0.958)	0.002	0.902 (0.838-0.971)	0.006	0.916 (0.849-0.988)	0.023
Within ≤ 60% per 10% increase	1450	924	17.50	0.958 (0.912-1.006)	0.084	0.97 (0.923-1.02)	0.239	0.986 (0.937-1.037)	0.579
Within > 60% per 10% increase	1093	514	10.13	1.294 (1.151-1.456)	< 0.001	1.174 (1.029-1.338)	0.017	1.174 (1.026-1.342)	0.020
Cancer-specify mortality
Any type per 10% increase	2543	1106	8.64	0.955 (0.925-0.985)	0.004	0.936 (0.905-0.968)	< 0.001	0.947 (0.915-0.980)	0.002
Within URBMI per 10% increase	1871	776	8.63	1.001 (0.955-1.048)	0.982	0.982 (0.932-1.034)	0.486	0.984 (0.934-1.036)	0.533
Within UEBMI per 10% increase	672	330	10.74	0.877 (0.808-0.951)	0.002	0.890 (0.818-0.969)	0.007	0.899 (0.825-0.981)	0.016
Within ≤ 60% per 10% increase	1450	741	11.74	0.976 (0.923-1.031)	0.381	0.992 (0.938-1.049)	0.776	1.010 (0.954-1.068)	0.742
Within > 60% per 10% increase	1093	365	6.01	1.380 (1.205-1.581)	< 0.001	1.273 (1.095-1.48)	0.002	1.269 (1.087-1.481)	0.003

¹Model A: We adjusted for demographic factors, including age, sex, marriage, nation, body mass index, Karnofsky performance status, base disease, pathological, tumor-node-metastasis.

²Model B: Based on model A, we additionally adjusted for treatment types, including radiotherapy, chemotherapy, surgery, immunotherapy, targeted.

³Model C: Based on model B, we additionally adjusted for blood index, including fibrinogen, β2 micro-globulin, lactate dehydrogenase, platelet-lymphocyte ratio, lymphocyte-monocyte ratio, neutrophil-lymphocyte ratio, albumin/globulin, cluster of differentiation 4/cluster of differentiation 8.

HR: Hazard ratio; CI: Confidence interval; URBMI: Urban and rural resident basic medical insurance; UEBMI: Urban employee basic medical insurance.