Exosomal biomarkers: A novel frontier in the diagnosis of gastrointestinal cancers

doi:10.4251/wjgo.v17.i4.103591

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Apr 15, 2025 (publication date) through Mar 28, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2025; 17(4): 103591
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.103591

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Figure 3 Clinical application of exosomal biomarkers for gastrointestinal diagnostic. Biopsies of exosomes include tumor tissue, blood, urine, saliva and feces. These sources contain cancer-derived exosome-encapsulated microRNAs, proteins and metabolic molecules. Treatment efficacy is monitored in real time by detecting and quantifying these molecular targets in association with tumor stage. miRNA: MicroRNA; LC-MS/MS: Liquid chromatography-tandem mass spectrometry; GC-MS: Gas chromatography-mass spectrometry; qRT-PCR: Quantitative reverse transcriptase polymerase chain reaction; FISH: Fluorescence in situ hybridization; WB: Western blot; ELISA: Enzyme-linked immunosorbent assay; HPLC-MS/MS: High performance liquid chromatography-tandem mass spectrometry.

Citation: Zhang Y, Yue NN, Chen LY, Tian CM, Yao J, Wang LS, Liang YJ, Wei DR, Ma HL, Li DF. Exosomal biomarkers: A novel frontier in the diagnosis of gastrointestinal cancers. World J Gastrointest Oncol 2025; 17(4): 103591
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/103591.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.103591