Exosomal biomarkers: A novel frontier in the diagnosis of gastrointestinal cancers

doi:10.4251/wjgo.v17.i4.103591

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Apr 15, 2025 (publication date) through Mar 31, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2025; 17(4): 103591
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.103591

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Figure 1 General illustration of exosome biogenesis and structural components. Membrane outgrowth from the endosomal system produces early endosomes and subsequently multivesicular bodies of intraluminal vesicles. Once formed, multivesicular body fuse with the plasma membrane and release intraluminal vesicle contents. The endosomal sorting complex machinery pathway, Alix and tetraspanin are involved in the transport and biogenesis of exosomes. ESCRT: Endosomal sorting complex required for transport; MVB: Multivesicular body; miRNA: MicroRNA.

Citation: Zhang Y, Yue NN, Chen LY, Tian CM, Yao J, Wang LS, Liang YJ, Wei DR, Ma HL, Li DF. Exosomal biomarkers: A novel frontier in the diagnosis of gastrointestinal cancers. World J Gastrointest Oncol 2025; 17(4): 103591
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/103591.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.103591