Identification of key hub genes associated with anti-gastric cancer effects of lotus plumule based on machine learning algorithms

Figure 7 Effect of mutations in hub genes on gastric cancer. A: Single nucleotide variation mutation sites and types of hub genes. The circle color represents the mutation type and the line length represents the mutation frequency; B: Waterfall plot of single nucleotide variation mutation frequency of hub genes. The upper bar indicates the proportion of hub gene mutations in the 23 samples; C: Bubble plots of heterozygous and pure heterozygous copy number variation mutations in the hub genes. The larger the bubble, the higher the proportion of mutations; D: Mutational associations of driver genes with the hub genes; E: Box plot of microsatellite instability expression levels of hub genes. CA9: Carbonic anhydrase 9; FBP1: Fructose-bisphosphatase 1; PRMT1: Protein arginine methyltransferase 1; AKR1B10: Aldo-keto reductase family 1 member B10; CNV: Copy number variation; SCNA: Somatic copy number alterations; TCGA: The Cancer Genome Atlas.