Identification of key hub genes associated with anti-gastric cancer effects of lotus plumule based on machine learning algorithms

Figure 2 Targets of LZX active ingredients and differentially expressed genes in gastric cancer. A: 279 intersection genes of GeneCards, GENENET, weighted gene co-expression network analysis and differential expressed genes (DEGs); B: 575 genes of LZX; C: All genes of gastric cancer and the number of targets of LZX active ingredients; D: 26 intersection genes of gastric cancer and LZX; E: Log₂ fold change values of the top 10 up- and down-regulated genes in the intersection targets, where blue and purple represent up- and down-regulated genes, respectively; F: Volcano plot of DEGs in GSE118916; G: Heatmap of DEGs in GSE118916: Comparing the normal group (N) with the tumor group (C); H: Principal co-ordinates analysis plot of the samples of the intersecting targets. Red dots represent normal group samples and green dots represent tumor group samples. LZX: Lotus plumule; GEO: Gene Expression Omnibus; WGCNA: Weighted gene co-expression network analysis; GC: Gastric cancer; PC: Principal component.