Centromere protein A knockdown inhibits rectal cancer through O6-methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis

Figure 7 Centromere protein A knockdown inhibited rectal cancer tumor growth in xenograft mice. A: Tumor images; B and C: Tumor volumes (B) and tumor weights (C) were recorded; D and E: CEPNA, O6-methylguanine DNA methyltransferase, and protein tyrosine phosphatase nonreceptor type 4 levels were detected using immunohistochemistry; F and G: The protein level of proliferation marker Ki67 protein was detected using immunohistochemistry. Data are presented as mean ± SE. ^aP < 0.05; ^bP < 0.01; CENPA: Centromere protein A; MGMT: O6-methylguanine DNA methyltransferase; PTPN4: Protein tyrosine phosphatase nonreceptor type 4; sh-CENPA: Short hairpin RNAs targeting Centromere protein A; sh-MGMT: Short hairpin RNAs targeting O6-methylguanine DNA methyltransferase; sh-PTPN4: Short hairpin RNAs targeting protein tyrosine phosphatase nonreceptor type 4.