Centromere protein A knockdown inhibits rectal cancer through O6-methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis

Figure 1 Centromere protein A is upregulated in rectal cancer. A: Centromere protein A (CENPA) expression in various cancer types in the UALCAN database (http://ualcan.path.uab.edu/index.html); B: Relative CENPA expression in rectal cancer tissues and normal tissues shown in UALCAN database; C and D: Relative CENPA protein level in rectal cancer tissues and adjacent tissues (n = 28 per group) was examined using Western blot analysis; E: Immunohistochemistry assay was used to examine CENPA protein levels in collected tissues; F and G: Relative expression of CENPA in SW480, HR8348, SW837, and SW1463 cells measured through Western blot analysis. Data are presented as mean ± SE. ^aP < 0.05; ^bP < 0.01; A: Adjacent; T: Tumor; CENPA: Centromere protein A.