Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk

Table 8 Logistic regression analyses of association between high-mobility group box 1 single nucleotide polymorphisms and lymph node status of colorectal cancer in different region

Genotype	Colon cancer								Rectum cancer
	Positive (n = 205)		Negative (n = 226)		Crude OR (95%CI)	P value	Adjusted OR (95%CI)1	P value1	Positive (n = 313)		Negative (n = 259)		Crude OR (95%CI)	P value	Adjusted OR (95%CI)1	P value1
	n	%	n	%					n	%	n	%
HMGB1 rs1412125 T > C
TT	95	47.03	120	54.30	1.00		1.00		164	53.42	127	50.80	1.00		1.00
TC	87	43.07	86	38.91	1.28 (0.86-1.91)	0.232	1.29 (0.86-1.93)	0.216	121	39.41	101	40.40	0.93 (0.65-1.32)	0.676	0.92 (0.65-1.32)	0.657
CC	20	9.90	15	6.79	1.68 (0.82-3.47)	0.157	1.69 (0.82-3.48)	0.157	22	7.17	22	8.80	0.77 (0.41-1.46)	0.430	0.78 (0.41-1.49)	0.455
TC + CC	107	52.97	101	45.70	1.34 (0.91-1.96)	0.136	1.35 (0.92-1.98)	0.126	143	46.58	123	49.20	0.90 (0.64-1.26)	0.538	0.90 (0.64-1.26)	0.531
TT + TC	182	90.10	206	93.21	1.00		1.00		285	92.83	228	91.20	1.00		1.00
CC	20	9.90	15	6.79	1.51 (0.75-3.04)	0.248	1.51 (0.75-3.03)	0.252	22	7.17	22	8.80	0.80 (0.43-1.48)	0.478	0.81 (0.44-1.51)	0.509
C allele	127	31.44	116	26.24					165	26.87	145	29.00
HMGB1 rs1045411 C > T
CC	127	62.87	152	68.78	1.00		1.00		188	61.24	160	64.00	1.00		1.00
CT	66	32.67	57	25.79	1.39 (0.91-2.12)	0.133	1.41 (0.92-2.16)	0.117	103	33.55	81	32.40	1.08 (0.76-1.55)	0.667	1.08 (0.75-1.55)	0.685
TT	9	4.46	12	5.43	0.90 (0.37-2.20)	0.813	0.90 (0.37-2.21)	0.814	16	5.21	9	3.60	1.51 (0.65-3.52)	0.336	1.57 (0.67-3.68)	0.297
CT + TT	75	37.13	69	31.22	1.30 (0.87-1.95)	0.201	1.32 (0.88-1.98)	0.182	119	38.76	90	36.00	1.13 (0.80-1.59)	0.503	1.13 (0.80-1.60)	0.503
CC + CT	193	95.54	209	94.57	1.00		1.00		291	94.79	241	96.40	1.00		1.00
TT	9	4.46	12	5.43	0.81 (0.34-1.97)	0.645	0.81 (0.33-1.97)	0.644	16	5.21	9	3.60	1.47 (0.64-3.39)	0.364	1.53 (0.66-3.55)	0.320
T allele	84	20.79	81	18.33					135	21.99	99	19.80

¹Adjusted for age, sex, smoking status, alcohol use and body mass index status.

OR: Odds ratio; CI: Confidence interval; HMGB1: High-mobility group box 1.