Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk

Table 7 Logistic regression analyses of association between high-mobility group box 1 single nucleotide polymorphisms and lymph node status of colorectal cancer patients

Genotype	Positive (n = 518)		Negative (n = 485)		Crude OR (95%CI)	P value	Adjusted OR (95%CI)1	P value
	n	%	n	%
HMGB1 rs1412125 T > C
TT	259	50.88	247	52.44	1.00		1.00
TC	208	40.86	187	39.70	1.06 (0.82-1.38)	0.661	1.05 (0.81-1.37)	0.700
CC	42	8.25	37	7.86	1.08 (0.67-1.74)	0.744	1.09 (0.68-1.76)	0.712
TC + CC	250	49.12	224	47.56	1.06 (0.83-1.37)	0.626	1.06 (0.82-1.36)	0.650
TT + TC	467	91.75	434	92.14	1.00		1.00
CC	42	8.25	37	7.86	1.06 (0.67-1.67)	0.820	1.07 (0.67-1.70)	0.776
C allele	292	28.68	261	27.71
HMGB1 rs1045411 C > T
CC	315	61.89	312	66.24	1.00		1.00
CT	169	33.20	138	29.30	1.21 (0.92-1.60)	0.167	1.21 (0.92-1.59)	0.182
TT	25	4.91	21	4.46	1.18 (0.65-2.15)	0.591	1.19 (0.65-2.17)	0.578
CT + TT	194	38.11	159	33.76	1.21 (0.93-1.57)	0.156	1.20 (0.93-1.57)	0.167
CC + CT	484	95.09	450	95.54	1.00		1.00
TT	25	4.91	21	4.46	1.11 (0.61-2.01)	0.738	1.12 (0.62-2.03)	0.718
T allele	219	21.51	180	19.11

¹Adjusted for age, sex, alcohol use and smoking status.

OR: Odds ratio; CI: Confidence interval; HMGB1: High-mobility group box 1.