Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk

Table 6 Stratified analyses between high-mobility group box 1 polymorphisms and colorectal cancer risk by site of tumor

Genotype	Controls (n=1303)		Colon cancer cases (n = 431)		Crude OR (95%CI)	P value	Adjusted OR (95%CI)1	P value1	Rectum cancer cases (n = 572)		Crude OR (95%CI)	P value	Adjusted OR (95%CI)1	P value1
	n	%	n	%					n	%
HMGB1 rs1412125 T > C
TT	731	56.23	215	50.83	1.00		1.00		291	52.24	1.00		1.00
TC	504	38.77	173	40.90	1.17 (0.93-1.47)	0.188	1.16 (0.92-1.46)	0.212	222	39.86	1.11 (0.90-1.36)	0.341	1.12 (0.91-1.39)	0.287
CC	65	5.00	35	8.27	1.83 (1.18-2.84)	0.007	1.81 (1.16-2.82)	0.009	44	7.90	1.70 (1.13-2.55)	0.010	1.69 (1.11-2.55)	0.014
TC + CC	569	43.77	208	49.17	1.24 (1.00-1.55)	0.053	1.23 (0.99-1.54)	0.064	266	47.76	1.17 (0.96-1.43)	0.114	1.19 (0.97-1.46)	0.097
TT + TC	1235	95.00	388	91.73	1.00		1.00		513	92.10	1.00		1.00
CC	65	5.00	35	8.27	1.72 (1.12-2.63)	0.013	1.70 (1.10-2.61)	0.016	44	7.90	1.63 (1.10-2.42)	0.016	1.61 (1.07-2.40)	0.022
C allele	634	24.38	243	28.72					310	27.83
HMGB1 rs1045411 C > T
CC	627	63.98	279	65.96	1.00		1.00		348	62.48	1.00		1.00
CT	307	31.33	123	29.08	0.86 (0.67-1.09)	0.208	0.85 (0.67-1.09)	0.200	184	33.03	1.03 (0.83-1.27)	0.812	1.01 (0.82-1.26)	0.900
TT	46	4.69	21	4.96	1.17 (0.69-1.97)	0.559	1.12 (0.66-1.90)	0.673	25	4.49	1.12 (0.68-1.82)	0.663	1.08 (0.65-1.78)	0.776
CT + TT	353	36.02	144	34.04	0.89 (0.71-1.12)	0.324	0.88 (0.70-1.12)	0.294	209	37.52	1.04 (0.84-1.27)	0.734	1.02 (0.83-1.26)	0.846
CC + CT	934	95.31	402	95.04	1.00		1.00		532	95.51	1.00		1.00
TT	46	4.69	21	4.46	1.23 (0.73-2.06)	0.435	1.18 (0.70-1.99)	0.535	25	4.49	1.11 (0.68-1.80)	0.686	1.07 (0.65-1.76)	0.788
T allele	399	20.36	165	19.50					234	21.01

¹Adjusted for age, sex, smoking status, alcohol use and body mass index status.

OR: Odds ratio; CI: Confidence interval; HMGB1: High-mobility group box 1.