Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk

Table 5 Stratified analyses between high-mobility group box 1 rs1045411 C > T polymorphism and colorectal cancer risk by sex, age, body mass index, smoking status and alcohol consumption

Variable	HMGB1 rs1045411 C > T (case/control)1			Adjusted OR (95% CI); P value2
	CC	CT	TT	Additive model	Homozygote model	Dominant model	Recessive model
Sex
Male	388/522	186/245	30/32	0.99 (0.78-1.26); 0.951	1.18 (0.70-1.99); 0.547	1.01 (0.81-1.27); 0.904	1.18 (0.70-1.98); 0.536
Female	239/301	121/179	16/21	0.87 (0.65-1.17); 0.366	1.03 (0.52-2.05); 0.927	0.89 (0.67-1.18); 0.418	1.08 (0.55-2.14); 0.817
Age
< 60	250/335	132/182	17/23	0.96 (0.73-1.26); 0.749	0.93 (0.51-1.72); 0.822	0.95 (0.74-1.24); 0.721	0.95 (0.52-1.73); 0.859
≥ 60	377/488	175/242	29/30	0.92 (0.72-1.18); 0.518	1.24 (0.70-2.21); 0.459	0.95 (0.75-1.21); 0.702	1.28 (0.72-2.25); 0.402
Smoking status
Never	472/647	226/343	30/45	0.89 (0.72-1.10); 0.285	0.92 (0.56-1.49); 0.720	0.90 (0.73-1.09); 0.278	0.95 (0.59-1.54); 0.837
Ever	155/176	81/81	16/8	1.12 (0.76-1.63); 0.576	2.08 (0.86-5.05); 0.107	1.20 (0.84-1.74); 0.320	2.00 (0.83-4.83); 0.121
Alcohol consumption
Never	522/736	250/382	38/46	0.92 (0.75-1.12); 0.397	1.15 (0.73-1.80); 0.547	0.94 (0.78-1.14); 0.544	1.18 (0.76-1.84); 0.463
Ever	105/87	57/42	8/7	1.12 (0.68-1.85); 0.650	0.81 (0.28-2.36); 0.692	1.08 (0.67-1.73); 0.767	0.77 (0.27-2.24); 0.635
BMI (kg/m2)
< 24	413/433	212/221	31/32	1.00 (0.79-1.26); 0.994	1.00 (0.60-1.68); 0.990	1.00 (0.80-1.25); 0.998	1.00 (0.60-1.67); 0.989
≥ 24	214/390	95/203	15/21	0.86 (0.64-1.17); 0.338	1.38 (0.69-2.75); 0.357	0.91 (0.69-1.21); 0.523	1.45 (0.73-2.87); 0.284

¹The genotyping was successful in 980 (97.71%) cases, and 1300 (99.77%) controls for HMGB1 rs1045411 C > T.

²Adjusted for age, sex, body mass index, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model.

OR: Odds ratio; CI: Confidence interval; BMI: Body mass index; HMGB1: High-mobility group box 1.