Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk

Table 4 Stratified analyses between high-mobility group box 1 rs1412125 T > C and colorectal cancer risk by sex, age, body mass index, smoking status and alcohol consumption

Variable	HMGB1 rs1412125 T > C (case/control)1			Adjusted OR (95% CI); P value2
	TT	TC	CC	Additive model	Homozygote model	Dominant model	Recessive model
Sex
Male	317/461	240/301	47/37	1.16 (0.93-1.45); 0.198	1.77 (1.12-2.81); 0.015	1.23 (0.99-1.53); 0.063	1.67 (1.06-2.62); 0.027
Female	189/270	155/203	32/28	1.11 (0.83-1.47); 0.494	1.77 (1.02-3.08); 0.043	1.18 (0.90-1.56); 0.230	1.69 (0.99-2.90); 0.055
Age
< 61	199/299	172/213	28/28	1.19 (0.92-1.55); 0.189	1.44 (0.85-2.44); 0.181	1.22 (0.95-1.57); 0.120	1.33 (0.79-2.22); 0.284
≥ 61	307/432	223/291	51/37	1.09 (0.86-1.39); 0.487	2.05 (1.27-3.31); 0.003	1.19 (0.95-1.50); 0.130	1.98 (1.24-3.16); 0.004
Smoking status
Never	371/573	297/409	60/53	1.11 (0.91-1.36); 0.306	1.73 (1.16-2.57); 0.007	1.18 (0.97-1.43); 0.090	1.65 (1.12-2.43); 0.012
Ever	135/158	98/95	19/12	1.21 (0.83-1.75); 0.320	1.76 (0.82-3.80); 0.148	1.27 (0.89-1.81); 0.185	1.64 (0.77-3.48); 0.201
Alcohol consumption
Never	416/650	327/457	67/57	1.11 (0.92-1.34); 0.285	1.80 (1.23-2.62); 0.002	1.19 (0.99-1.42); 0.067	1.72 (1.19-2.48); 0.004
Ever	90/81	68/47	12/8	1.29 (0.79-2.09); 0.310	1.37 (0.53-3.55); 0.522	1.30 (0.82-2.06); 0.271	1.24 (0.49-3.14); 0.657
BMI (kg/m2)
< 24	338/379	262/273	56/34	1.10 (0.88-1.38); 0.397	1.90 (1.21-3.00); 0.006	1.19 (0.96-1.48); 0.114	1.82 (1.17-2.84); 0.008
≥ 24	168/352	133/231	23/31	1.21 (0.91-1.60); 0.196	1.58 (0.89-2.81); 0.122	1.25 (0.95-1.64); 0.111	1.46 (0.83-2.56); 0.192

¹The genotyping was successful in 980 (97.71%) cases, and 1300 (99.77%) controls for HMGB1 rs1412125 T > C.

²Adjusted for age, sex, body mass index, smoking status and alcohol consumption (besides stratified factors accordingly) in a logistic regression model.

OR: Odds ratio; CI: Confidence interval; BMI: Body mass index; HMGB1: High-mobility group box 1.