Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk

Table 3 Logistic regression analyses of associations between high-mobility group box 1 rs1412125 T > C polymorphisms and colorectal cancer risk

Genotype	Cases (n = 1003)		Controls (n = 1303)		Crude OR (95%CI)	P value	Adjusted OR (95%CI)1	P value
	n	%	n	%
HMGB1 rs1412125 T > C
TT	506	51.63	731	56.23	1.00		1.00
TC	395	40.31	504	38.77	1.13 (0.95-1.35)	0.161	1.14 (0.95-1.35)	0.160
CC	79	8.06	65	5.00	1.76 (1.24-2.49)	0.002	1.74 (1.22-2.47)	0.002
TC + CC	474	48.37	569	43.77	1.20 (1.02-1.42)	0.029	1.20 (1.02-1.43)	0.032
TT + TC	901	91.94	1235	95.00	1.00		1.00
CC	79	8.06	65	5.00	1.67 (1.19-2.34)	0.003	1.64 (1.17-2.32)	0.005
C allele	553	28.21	634	24.38
HMGB1 rs1045411 C > T
CC	627	63.98	823	63.31	1.00		1.00
CT	307	31.33	424	32.62	0.95 (0.79-1.14)	0.579	0.94 (0.78-1.13)	0.495
TT	46	4.69	53	4.08	1.14 (0.76-1.71)	0.532	1.10 (0.72-1.66)	0.664
CT + TT	353	36.02	477	36.69	0.97 (0.82-1.15)	0.742	0.96 (0.80-1.14)	0.615
CC + CT	934	95.31	1247	95.92	1.00		1.00
TT	46	4.69	53	4.08	1.16 (0.77-1.74)	0.475	1.12 (0.74-1.69)	0.589
T allele	399	20.36	530	20.38

¹Adjusted for age, sex, body mass index, smoking and drinking status.

OR: Odds ratio; CI: Confidence interval; HMGB1: High-mobility group box 1.