Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism

Figure 5 Network pharmacology and molecular docking analysis of chlorogenic acid intervention targets. A: Protein-protein interaction network of the 14 chlorogenic acid intervention targets; B: Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis results; C: Molecular docking results of chlorogenic acid with peroxisome proliferator activated receptor gamma, fatty acid binding protein 4, glutathione peroxidase 4, and cystine glutamate reverse transporter. GPX4: Glutathione peroxidase 4; PTGS2: Prostaglandin endoperoxide synthase 2; xCT: Cystine glutamate reverse transporter; AKR1C3: Aldo-keto reductase family 1 member C3.