Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism

Figure 4 Construction and evaluation of the risk assessment system for chlorogenic acid intervention targets and nomogram. A: Forest plot of univariate and multivariate Cox regression analysis of chlorogenic acid intervention targets; B: Construction of nomogram integrating risk score and clinical information; C: Time-receiver operating characteristic curve of the risk assessment system; D: Kaplan-Meier curve comparing the survival between high- and low-risk groups; E-G: Calibration plots of the nomogram for 1-year, 3-year, and 5-year survival (mean ± SD, n = 374). HR: Hazard ratios; CI: Confidence intervals; T: Tumor; N: Node; M: Metastasis; TPR: True positive rate.