Significance of monitoring imatinib plasma concentration in second-line treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors

doi:10.4251/wjgo.v17.i3.98746

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Mar 15, 2025; 17(3): 98746
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.98746

Table 5 Adverse effects in the dose-escalation group, n (%)

Types of adverse reactions	LP (n = 14)		HP (n = 18)
Types of adverse reactions	Before¹	After²	Before¹	After²
Fatigue	0 (0.0)	2 (14.3)	2 (11.1)	10 (55.6)^b
Rash	3 (21.4)	7 (50.0)	8 (44.4)	12 (66.7)
Muscle spasm	0 (0.0)	1 (7.1)	4 (22.2)	7 (38.9)
Anemia	5 (35.7)	10 (71.4)	13 (72.2)	15 (83.3)
Gastrointestinal reactions	2 (14.3)	9 (64.3)^b	4 (22.2)	18 (100.0)^b
Edema	4 (28.6)	8 (57.1)	10 (55.6)	17 (94.4)^a
Liver dysfunction	0 (0.0)	1 (7.1)	2 (11.1)	2 (11.1)
Granulocytopenia	3 (21.4)	5 (35.7)	8 (44.4)	11 (61.1)

^aP < 0.05.

^bP < 0.01.

¹Before increasing the dose of imatinib.

²After increasing the dose of imatinib.

HP: High plasma concentration group; LP: Low plasma concentration group.

Citation: Li HT, Du YY, Huang Z, Li JJ, Zhang J. Significance of monitoring imatinib plasma concentration in second-line treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors. World J Gastrointest Oncol 2025; 17(3): 98746
URL: https://www.wjgnet.com/1948-5204/full/v17/i3/98746.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i3.98746