Significance of monitoring imatinib plasma concentration in second-line treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors

doi:10.4251/wjgo.v17.i3.98746

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Mar 15, 2025 (publication date) through Feb 21, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Mar 15, 2025; 17(3): 98746
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.98746

Table 4 Comparison of disease control rate and objective response rate between the two groups of patients in group high plasma concentration group, n (%)

Group	n	CR	PR	SD	PD	DCR	ORR
Group A	18	0 (0)	0 (0)	6 (33.3)	12 (66.6)	6 (33.3)	0 (0)
Group B	29	0 (0)	4 (13.7)	17 (58.6)	8 (27.5)	21 (72.4)	4 (13.8)
χ²						6.94	-
P value						0.008^a	0.28

^aP < 0.05.

CR: Complete response; DCR: Disease control rate; ORR: Objective response rate; PD: Progressive disease; PR: Partial response; SD: Stable disease.

Citation: Li HT, Du YY, Huang Z, Li JJ, Zhang J. Significance of monitoring imatinib plasma concentration in second-line treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors. World J Gastrointest Oncol 2025; 17(3): 98746
URL: https://www.wjgnet.com/1948-5204/full/v17/i3/98746.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i3.98746