Significance of monitoring imatinib plasma concentration in second-line treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors

doi:10.4251/wjgo.v17.i3.98746

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Mar 15, 2025 (publication date) through Feb 21, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Mar 15, 2025; 17(3): 98746
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.98746

Table 3 Comparison of disease control rate and objective response rate between the two groups of patients in group low plasma concentration group, n (%)

Group	n	CR	PR	SD	PD	DCR	ORR
Group A	14	0 (0)	2 (14.2)	8 (57.1)	4 (28.5)	10 (71.4)	3 (21.4)
Group B	14	0 (0)	6 (42.8)	3 (21.4)	5 (35.7)	9 (64.3)	6 (42.9)
χ²						-	-
P value						> 0.99	0.42

CR: Complete response; DCR: Disease control rate; ORR: Objective response rate; PD: Progressive disease; PR: Partial response; SD: Stable disease.

Citation: Li HT, Du YY, Huang Z, Li JJ, Zhang J. Significance of monitoring imatinib plasma concentration in second-line treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors. World J Gastrointest Oncol 2025; 17(3): 98746
URL: https://www.wjgnet.com/1948-5204/full/v17/i3/98746.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i3.98746