DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein

Figure 1 The expression and methylation levels of microRNA-125a-5p in gastric cancer tissues and gastric cancer cell lines. A: MicroRNA (miR)-125a-5p expression in clinical samples detected by real-time polymerase chain reaction (RT-qPCR); B: MiR-125a-5p promoter methylation level in clinical samples detected by methylation-specific polymerase chain reaction; C: RT-qPCR detection of miR-125a-5p expression in cells; D: Methylation-specific polymerase chain reaction detection of the miR-125a-5p promoter methylation level in cells. ^cP < 0.001. miR: MicroRNA; GC: Gastric cancer; M: Methylation; U: Unmethylated.