Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer: A systematic review and meta-analysis

doi:10.4251/wjgo.v17.i3.98103

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Mar 15, 2025; 17(3): 98103
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.98103

Table 2 Effect estimates and study characteristics of all identified studies

Study	pN HR (95%CI)	Cutoff value	LNR HR (95%CI)	Cutoff value	LODDS HR (95%CI)	Cutoff value	Statistical analysis	Study design	NAT	Surgery (D2 vs D1 and D2)
Villalabeitia Ateca et al[28]	1.86 (1.25-2.77)	7^th (N0, N1, N2, N3)	2.83 (1.01-7.93)	0/0.33/0.66	2.88 (1.5-5.21)	-1.5/-1/-0.5/0	MA	R	Y	D1 and D2
Gu et al[29]	1.216 (1.149-1.286)	8^th (N0, N1, N2, N3a, N3b)	4.00 (2.15-7.44)	0/0.067/0.3/0.7	4.38 (2.30-8.33)	-1.5/-1/-0.5/0	UA	R	N	NA
Cao et al[30]	2.012 (1.113-2.868)	8^th (N0, N1, N2, N3a, N3b)	1.77 (1.023-2.38)	0/0.28/1	1.875 (1.101-2.877)	-0.5/0/0.5	MA	R	N	D2
Pan et al[31]	4.64 (2.41-8.92)	8^th (N0, N1, N2, N3a, N3b)	4.37 (1.99-9.61)	0/0.2/0.5	3.15 (1.64-6.03)	-1.5/-1/-0.5/0	UA	R	Y	D2
Lee et al[32]	2.4 (1.3-4.41)	8^th (N0, N1, N2, N3a, N3b)	2.33 (1.30-4.19)	0/0.1/0.2/0.3	2.39 (1.24-4.59)	-4/-2.5/-2/-0.5	MA	R	Y	D1 and D2
Calero et al[33]	1.02 (0.99-1.04)	7^th (N0, N1, N2, N3)	0.99 (0.97-1.01)	0/0.25/0.75	1.61 (1.2-2.25)	-5/-3/-1/3	MA	R	N	D1 and D2
Aurello et al[19]	1.648 (1.224-2.219)	7^th (N0, N1, N2, N3)	1.774 (1.29-2.43)	0/0.1/0.25	3.666 (1.515-8.867)	-1/-0.5/0/0.5	MA	R	N	D1 and D2
Liu et al[22]	5.08 (2.72-9.48)	7^th (N0, N1, N2, N3)	5.21 (3.01-8.99)	0/0.1/0.4	3.69 (1.87-7.27)	-1.5/-1/-0.5	UA	R	N	D2
Sun et al[34]	1.578 (1.465-1.699)	6^th (N0, N1, N2, N3)	1.481 (1.39-1.57)	0/0.2/0.5	1.445 (1.369-1.525)	-1.5/-1/-0.5/0	MA	R	Y	D2
Koh et al[35]	20.39 (7.56-55.03)	8^th (N0, N1, N2, N3a, N3b)	19.55 (6.17-61.9)	0/0.2/0.5	18.65 (7.54-46.09)	-0.5/0/0.5	MA	R	N	D1 and D2
Tóth et al[36]	2.87 (1.77-4.66)	7^th (N0, N1, N2, N3)	2.56 (1.53-4.28)	0/0.2/0.5	4.32 (1.83-10.16)	-1.125/-0.25/0.75	MA	R	N	D1 and D2
Jian-Hui et al[14]	2.81 (1.53-5.15)	7^th (N0, N1, N2, N3)	2.86 (1.38-5.91)	0/0.1/0.25	4.63 (1.79-11.96)	-1.5/-1/0	MA	R	N	D2

LNR: Lymph node ratio; LODDS: Log odds of positive lymph nodes; pN: Pathological lymph nodes; NAT: Neoadjuvant therapy; HR: Hazard ratio; CI: Confidence interval; NA: Not available; Y: Yes; N: No; MA: Multivariate statistical analysis models; UA: Univariate statistical analysis models; R: Retrospective.

Citation: Cheng M, Yu Y, Watanabe T, Yoshimoto Y, Kaji S, Yube Y, Kaneda M, Orita H, Mine S, Wu YY, Fukunaga T. Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer: A systematic review and meta-analysis. World J Gastrointest Oncol 2025; 17(3): 98103
URL: https://www.wjgnet.com/1948-5204/full/v17/i3/98103.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i3.98103