Transmembrane protein 176B promotes epithelial-mesenchymal transition in colorectal cancer through inflammasome inhibition

Figure 2 Short hairpin RNA targeting transmembrane protein 176B inhibits cancer promotion in colon cancer mice. A and B: The TUNEL-positive cells were stained in colon tumor tissues of mice with magnifications of 200 × (scale bar 100 μm) and the percentage of positive cells being calculated; C and D: Immunohistochemistry staining detected the positive expression of Ki67 in colon tumor tissues of mice, with magnifications of 200 × (scale bar 100 μm) and 400 × (scale bar 50 μm). Average optical density is the average optical density, calculated by analyzing the total optical density and area of the image using ImageJ. ^aP < 0.05; ^bP < 0.01. sh-TMEM176B: Short hairpin RNA targeting transmembrane protein 176B; NC: Negative control; sh-NC: shRNA-negative control; AOD: Average optical density.