To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway

doi:10.4251/wjgo.v17.i3.102187

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Mar 15, 2025; 17(3): 102187
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.102187

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Figure 6 Schematic of the interaction between tetrahydrocurcumin and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. Tetrahydrocurcumin has strong binding activity, forming nine hydrogen bonds in the hydrophobic pocket formed by TYR836, VAL851, SER854, ASP810, ASP933, and SER774 amino acid residues of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.

Citation: Bao ZC, Liu ZD, Zhang Y, Dai HJ, Jia H, Ren F, Li N, Zhao L, Wang YW, Lv SY, Zhang Y. To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway. World J Gastrointest Oncol 2025; 17(3): 102187
URL: https://www.wjgnet.com/1948-5204/full/v17/i3/102187.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i3.102187