To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway

doi:10.4251/wjgo.v17.i3.102187

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Mar 15, 2025; 17(3): 102187
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.102187

Table 2 Docking scores of tetrahydrocurcumin with core target molecules

Name	PDB ID	Target protein scoring, total score
PIK3CA	5DXT	9.2428
KDR	2XIR	9.1786
EGFR	3POZ	9.0041
MMP9	6ESM	8.7419
HSP90AA1	1BYQ	8.5337
STAT3	5AX3	7.9753
PPARG	3B1M	7.9106
MTOR	4DRI	7.8581
AR	1T65	7.6085
AKT1	4GV1	6.6415
TP53	1XQH	6.5781
CASP3	1NMS	6.2940
MDM2	4HG7	6.1486
ESR1	3CBP	5.9387
HIF1A	6GMR	5.6041
SRC	1O41	4.2536

PIK3CA: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; KDR: Kinase insert domain receptor; EGFR: Epidermal growth factor receptor; MMP9: Matrix metallopeptidase 9; HSP90AA1: Heat shock protein 90 alpha family class A member 1; STAT3: Signal transducer and activator of transcription 3; PPARG: Peroxisome proliferator activated receptor gamma; MTOR: Mammalian target of rapamycin; AR: Androgen receptor; CASP3: Caspase-3; MDM2: Murine double minute 2; ESR1: Estrogen receptor 1; HIF1A: Hypoxia inducible factor 1 subunit alpha; SRC: Proto-oncogene tyrosine-protein kinase Src.

Citation: Bao ZC, Liu ZD, Zhang Y, Dai HJ, Jia H, Ren F, Li N, Zhao L, Wang YW, Lv SY, Zhang Y. To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway. World J Gastrointest Oncol 2025; 17(3): 102187
URL: https://www.wjgnet.com/1948-5204/full/v17/i3/102187.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i3.102187