IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation

Figure 7 The ERK inhibitor can block the effects of IL-22 on the proliferation, migration, and invasion of cholangiocarcinoma cells. A: The images of colony formation of HuCCT1 and RBE cells after different treatments and the results of quantitative analysis comparing each group; B: EdU staining images of HuCCT1 and RBE cells from different treatment groups, along with quantitative analysis results comparing each group; C: Migration and invasion images of HuCCT1 and RBE cells from different treatment groups, along with the results of quantitative analysis comparing each group; D: Wound healing images of HuCCT1 and RBE cells from different treatment groups, along with the results of quantitative analysis comparing each group. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. NC: Negative control.