Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma

Figure 5 Biological functions of transmembrane protein 106C in hepatocellular carcinoma cells. A: Transmembrane protein 106C (TMEM106C) mRNA was significantly overexpressed in 248 hepatocellular carcinoma (HCC) tissue compared to 248 paired normal liver tissue samples; B: TMEM106C protein was expressed in the cytoplasm and membranes of HCC tumor cells; C: TMEM106C was successfully knocked out using the clustered regularly interspaced short palindromic repeats gene editing technology; D and E: TMEM106C knockout significantly attenuated the proliferation, migrated and invaded ability of HCC cells. ^bP < 0.01. ^cP < 0.001. ^dP < 0.0001. HCC: Hepatocellular carcinoma; KO: Knockout; PCR: Polymerase chain reaction; TMEM106C: Transmembrane protein 106C.