Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma

Figure 1 Putative clinicopathological significance of transmembrane protein 106C in pan-cancers. A: Relative expression values of transmembrane protein 106C (TMEM106C) in pan-cancers; B: Discriminatory ability of TMEM106C in pan-cancers; C: Univariate Cox regression analysis of TMEM106C in pan-cancers; D: Kaplan-Meier survival analysis of TMEM106C in pan-cancers. P values of Wilcoxon test. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. ^dP < 0.0001. ACC: Adrenocortical carcinoma; ALL: Acute lymphoblastic leukemia; AUC: Area under the curve; BLCA: Bladder urothelial carcinoma; BRCA: Breast invasive carcinoma; CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL: Cholangiocarcinoma; COAD: Colon adenocarcinoma; COADREAD: Colon adenocarcinoma/rectum adenocarcinoma; DLBC: Lymphoid neoplasm diffuse large B-cell lymphoma; ESCA: Esophageal carcinoma; GBM: Glioblastoma multiforme; GBMLGG: Glioblastoma and low-grade glioma; H: Transmembrane protein 106C-high expression group; HNSC: Head and neck squamous cell carcinoma; KICH: Kidney chromophobe; KIPAN: Pan-kidney cohort (kidney chromophobe + kidney renal clear cell carcinoma + kidney renal papillary cell carcinoma); KIRC: Kidney renal clear cell carcinoma; KIRP: Kidney renal papillary cell carcinoma; L: Transmembrane protein 106C-low expression group; LAML: Acute myeloid leukemia; LGG: Brain lower grade glioma; LIHC: Liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; LUSC: Lung squamous cell carcinoma; MESO: Mesothelioma; NB: Neuroblastoma; OV: Ovarian serous cystadenocarcinoma; PAAD: Pancreatic adenocarcinoma; PCPG: Pheochromocytoma and paraganglioma; PRAD: Prostate adenocarcinoma; READ: Rectum adenocarcinoma; SARC: Sarcoma; STAD: Stomach adenocarcinoma; SKCM: Skin cutaneous melanoma; STES: Stomach and esophageal carcinoma; TARGET: Therapeutically applicable research to generate effective treatments; TCGA: The cancer genome atlas; TGCT: Testicular germ cell tumors; THCA: Thyroid carcinoma; THYM: Thymoma; UCEC: Uterine corpus endometrial carcinoma; UCS: Uterine carcinosarcoma; UVM: Uveal melanoma; WT: High-risk Wilms tumor.