Retrospective Study
Copyright ©The Author(s) 2025.
World J Gastrointest Oncol. Feb 15, 2025; 17(2): 101780
Published online Feb 15, 2025. doi: 10.4251/wjgo.v17.i2.101780
Table 2 Comparison of clinical characteristics between traditional serrated adenomas without and with dysplasia or adenocarcinoma, n (%)
Variables
TSAOs (n = 122)
TSADs (n = 71)
P value
Age (years), mean ± SD (range)61.1 ± 14.5 (18.0-84.0)66.7 ± 11.8 (36.0-85.1)0.072
Sex0.234
    Male63 (51.6)30 (42.3)
    Female59 (48.4)41 (57.7)
BMI (n = 499), mean ± SD (range)24.1 ± 3.7 (17.4-37.7)23.7 ± 2.9 (17.7-30.6)0.128
Obesity0.726
    Underweight (< 18.5)3 (2.5)3 (4.2)
    Normal (18.5-23.0)46 (37.7)30 (42.3)
    Overweight (23.0-25.0)31 (25.4)14 (19.7)
    Obesity (≥ 25.0)42 (34.4)24 (33.8)
Alcohol0.177
    None52 (42.6)37 (52.1)
    Quit31 (25.4)20 (28.2)
    Current39 (32.0)14 (19.7)
Smoking0.681
    None82 (67.2)52 (73.2)
    Quit23 (18.9)11 (15.5)
    Current17 (13.9)8 (11.3)
    Hypertension45 (36.9)36 (50.7)0.061
    Diabetes mellitus29 (23.8)11 (15.5)0.171
    Dyslipidemia21 (17.2)10 (14.1)0.568
Anti-platelet agent (n = 49)0.521
    Aspirin23 (18.9)9 (12.7)
    Warfarin/NOAC3 (2.5)2 (2.8)
    Dual anti-platelet agent9 (7.4)3 (4.2)
History of colorectal cancer16 (13.1)11 (15.5)0.671
Symptom0.051
    None111 (91.0)57 (80.3)
    Gastrointestinal bleeding10 (8.2)14 (19.7)
    Obstruction1 (0.8)0 (0.0)
Lesion-related factors
    Size (mm), mean ± SD (range)12.7 ± 8.0 (3.0-55.0)27.3 ± 15.9 (5.0-70.0)0.003
    Diminutive (1-5 mm)16 (13.1)0 (0.0)
    Small (6-9 mm)31 (25.4)15 (21.1)
    Large (> 10 mm)75 (61.5)56 (78.9)
Location0.177
    Cecum1 (0.8)2 (2.8)
    Ascending colon13 (10.7)14 (19.7)
    Transverse colon12 (9.8)8 (11.3)
    Descending colon8 (6.6)1 (1.4)
    Sigmoid colon42 (34.4)18 (25.4)
    Rectum46 (37.7)28 (39.4)
Color0.001
    White63 (51.6)19 (26.8)
    Red59 (48.4)52 (73.2)
Morphology (Paris classification)0.005
    0-Ip, 0-Isp53 (43.4)32 (45.1)
    0-Is35 (28.7)32 (45.1)
    0-IIa30 (24.6)4 (5.6)
    0-IIa + IIc4 (3.3)3 (4.2)
Border< 0.001
    Distinct114 (93.4)50 (70.4)
    Irregular8 (6.6)21 (29.6)
Mucosal surface0.058
    Smooth62 (50.8)27 (38.0)
    Lobular60 (49.2)44 (62.0)
Associated lesion (n = 104, 53.9%)
    Non-neoplastic lesions (n = 17, 8.8%)5 (4.2)12 (16.2)< 0.001
    Hyperplastic polyp5 (4.2)12 (16.2)
    Neoplastic lesions (n = 87, 45.1%)48 (40.3)39 (52.7)< 0.001
    Sessile serrated lesion1 (0.8)1 (1.4)
    Traditional serrated adenoma3 (2.5)7 (9.5)
    Conventional adenoma with LGD37 (31.1)25 (33.8)
    Conventional adenoma with HGD/ADC7 (5.9)6 (8.1)
Procedure-related factors
Removal methods< 0.001
    Cold biopsy1 (0.8)0 (0.0)
    Cold EMR6 (4.9)0 (0.0)
    Conventional EMR97 (79.5)24 (44.4)
    ESD13 (10.7)22 (40.7)
    Operation3 (2.5)8 (14.8)
    Observation2 (1.6)0 (0.0)
Post-procedural complications (n = 93, 48.2%)< 0.001
    Bleeding44 (36.1)48 (67.6)
    Perforation1 (0.8)0 (0.0)
Treatment method of complication< 0.001
    APC15 (12.3)3 (4.2)
    Coagrasper17 (13.9)18 (25.4)
    Hemoclipping13 (10.7)27 (38.0)