Protein tyrosine phosphatase nonreceptor 2: A New biomarker for digestive tract cancers

Table 1 Recent findings of the clinicopathological studies in gastrointestinal cancers related to protein tyrosine phosphatase nonreceptor 2

Ref.	Organ	Expression	Clinicopathologic parameters	Methods	Prognosis	Therapy related findings
Chen et al[29]	Esophagus	High	NS	Oncomine, Ualcan, TCGA data analysis	NS	-
Tang et al[1]	Esophagus	High	-	TCGA, GTEx, CGGA, GEO, cBioPortal, STRING, TISCH, TIMER2.0, ESTIMATE, TIDE data analysis	NS	Positive correlation with TMB and higher TIDE scores; Poor response to therapy
Chen et al[29]	Stomach	High	NS	Oncomine,Ualcan, TCGA data analysis	NS	-
Tang et al[1]	Stomach	High	-	TCGA, GTEx, CGGA, GEO,c BioPortal, STRING, TISCH, TIMER2.0, ESTIMATE, TIDE data analysis	NS	Positive correlation with TMB, MSI, tumor purity, polyploidy and HRD
Chen et al[29]	Colon	High	NS	Oncomine, Ualcan, TCGA data	NS	-
Tang et al[1]	Colon	High	-	TCGA, GTEx, CGGA, GEO, cBioPortal, STRING, TISCH, TIMER2.0, ESTIMATE, TIDE data analysis	NS	Positive correlation with high immune scores; Positive correlation with neoantigems; Negative correlation with tumor purity, polyploidy and HRD
Zhang et al[18]	Pancreas	Down regulated	-	Human tumor tissue, IHC, RT-PCR, IF, WB, CC, AE	Poor prognosis	-
Kuang et al[25]	Pancreas	High	Positive correlation with stage	Human tumor tissue, IHC, RT-PCR, IF, WB, CC, AE	Poor prognosis; Independent prognostic	Positive correlation with high immune scores
Tang et al[1]	Pancreas	High	-	TCGA, GTEx, CGGA, GEO, cBioPortal, STRING, TISCH, TIMER2.0, ESTIMATE, TIDE data analysis	Poor prognosis	Positive correlation with high immune scores; Positive correlation with HRD, TMB, MSI, tumor purity, polyploidy and HRD
Lee et al[27]	Liver (HCC)	Down regulated	Positive correlation with stage	Human tumor tissue	Poor prognosis	-
Tang et al[1]	Liver (HCC)	High	-	TCGA, GTEx, CGGA, GEO, c BioPortal, STRING, TISCH, TIMER2.0, ESTIMATE, TIDE data analysis	NS	Positive correlation with high immune scores; Negative correlation with TMB and tumor purity; Positive correlation with HRD and TIDE scores; Poor response to therapy
Tang et al[1]	Liver (CHOL)	High	-	TCGA, GTEx, CGGA, GEO,c BioPortal, STRING, TISCH, TIMER2.0, ESTIMATE, TIDE data analysis	NS	NS
Li et al[10]	Liver (HCC)	High	Positive correlation with preoperative alfa-protein	TCGA data analysis	Poor prognosis Independent prognostic	Higher immune cell infiltration, EMT and angiogenesis; Positive correlation with TGF-β, Notch and Hedgehog signaling pathways upregulation

Ualcan: The University of Alabama at Birmingham Cancer data analysis Portal; TCGA: The Cancer Genome Atlas; GTEX: Genotype tissue expression project; CGGA: Chinese Glioma Genome Atlas; GEO: Gene expression Omnibus database; STRING: Functional protein association networks; TISCH: Tumor Immune Single-cell Hub; TIMER 2.0: Web server for analysis of tumor-infiltrating immune cells; -: Not performed; TMB: Tumor mutation burden; TIDE: Tumor immune disfunction and exclusion; IHC: Immunohistochemistry; RT-PCR; Reverse transcriptase polymerase chain reaction; IF: Immunofluorescence ; WB: Western blotting; CC: Cell culture; AE: Animal experiment; MSI: Microsatellite instability; HRD: Homologous recombination deficiencies; HCC: Hepatocellular carcinoma; CHOL: Cholangiocarcinoma; EMT: Epithelial-to-mesenchymal transition; NS: Not significant.