BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

Figure 7 Anti-cancer effect of BIBR1532 in an esophageal squamous cell carcinoma xenograft mouse model. A-C: Tumor images (A), growth curves (B), and tumor weights (C) obtained from xenograft tumors derived from KYSE150 cells treated with BIBR1532 (50 mg/kg); D and E: Expression of human telomerase reverse transcriptase, Ki-67, and γ-H2AX in xenografted tumor tissues evaluated by immunohistochemistry (D) and Western blotting (E); F: Macroscopic images of the heart, liver, spleen, lungs, and kidneys of nude mice treated with BIBR1532 or DMSO; G: Hematoxylin and eosin staining of the heart, liver, spleen, lung, and kidney tissues from nude mice treated with BIBR1532 or DMSO. ^aP < 0.05 was compared with the control group respectively. P < 0.05 was considered statistically significant. hTERT: Human telomerase reverse transcriptase; γ-H2AX: Phosphorylated histone H2AX.