Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

Table 3 Logistic analysis for exploration of risk factors of any postoperative complications of patients who underwent laparoscopic pancreatoduodenectomy

Variables	Univariate analysis1		Multivariate analysis1		Univariate analysis2		Multivariate analysis2
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Sex		0.766				0.095		0.528
Male	1.000				1.000		1.000
Female	0.957 (0.714-1.281)				0.729 (0.502-1.057)		0.872 (0.570-1.334)
Age		0.268				0.046		0.209
< 65	1.000				1.000		1.000
≥ 65	1.173 (0.885-1.555)				1.417 (1.006-1.998)		1.266 (0.876-1.829)
Pathology		0.203				0.117
Benign tumors	1.000				1.000
Malignant tumors	1.239 (0.891-1.723)				1.411 (0.918-2.169)
ECOG score		0.245				0.010		0.107
0-1	1.000				1.000		1.000
2	1.339 (0.819-2.190)				2.005 (1.179-3.410)		1.637 (0.898-2.982)
Preoperative biliary drainage		0.047				0.419
Yes	1.000		1.000	0.001	1.000
No	1.488 (1.005-2.205)		2.160 (1.387-3.364)		1.227 (0.747-2.017)
Hypertension		0.510				0.802
No	1.000				1.000
Yes	1.110 (0.813-1.516)				1.051 (0.714-1.545)
Diabetes mellitus		0.568				0.012		0.031
No	1.000				1.000		1.000
Yes	1.107 (0.781-1.569)				1.887 (1.150-3.096)		1.773 (1.054-2.983)
Pancreatitis		0.194				0.633
No	1.000				1.000
Yes	1.402 (0.842-2.335)				1.159 (0.633-2.119)
Abdominal surgery history		0.276				0.170
No	1.000				1.000
Yes	1.400(0.765-2.564)				1.596 (0.818-3.144)
Smoking		0.511				0.253
No	1.000				1.000
Yes	1.103 (0.824-1.476)				1.228 (0.863-1.747)
Alcohol consumption		0.258				0.272
No	1.000				1.000
Yes	1.188 (0.881-1.602)				1.224 (0.854-1.756)
BMI		0.115				0.271
< 25	1.000				1.000
≥ 25	1.259 (0.945-1.676)				1.222 (0.855-1.747)
Operation time	1.001 (0.999-1.002)	0.484			1.001 (0.999-1.003)	0.408
Blood loss	1.000 (0.999-1.001)	0.956			1.000 (0.998-1.001)	0.533
Intraoperative blood transfusion		0.004		0.890		0.096		0.660
No	1.000		1.000		1.000		1.000
Yes	1.572 (1.154-2.140)		1.025 (0.722-1.455)		1.364 (0.946-1.966)		1.102 (0.715-1.700)
ASA score		0.475				0.496
II	1.000				1.000
III	1.111 (0.833-1.481)				1.130 (0.795-1.606)
RDW		< 0.001		< 0.001		< 0.001		< 0.001
< 15.4	1.000		1.000		1.000		1.000
≥ 15.4	3.537 (2.553-4.900)		2.973 (2.032-4.350)		3.603 (2.525-5.141)		3.138 (2.042-4.824)
Hemoglobin, g/L		0.212				0.024		0.426
< 115	1.000				1.000		1.000
≥ 115	0.813 (0.588-1.125)				0.647 (0.443-0.944)		0.823 (0.509-1.331)
Leucocytes, 109/L		0.250				0.047		0.533
< 9.5	1.000				1.000		1.000
≥ 9.5	1.308 (0.827-2.068)				1.675 (1.006-2.789)		1.198 (0.679-2.113)
Platelet, 109/L		0.003		0.093		0.996
< 350	1.000		1.000		1.000
≥ 350	1.894 (1.247-2.878)		1.493 (0.935-2.383)		1.001 (0.605-1.657)
Lymphocyte, 109/L		0.225				0.612
< 3.2	1.000				1.000
≥ 3.2	2.771 (0.534-14.368)				1.532 (0.295-7.968)
AST, U/L		0.002		0.190		0.016		0.649
< 35	1.000		1.000		1.000		1.000
≥ 35	1.610 (1.191-2.177)		1.617 (0.788-3.320)		1.618 (1.094-2.393)		1.229 (0.505-2.991)
ALT, U/L		0.042		0.731		0.035		0.651
< 40	1.000		1.000		1.000		1.000
≥ 40	1.363 (1.011-1.837)		1.140 (0.541-2.403)		1.516 (1.031-2.231)		1.226 (0.508-2.959)
GGT, U/L		0.004		0.186		0.006		0.454
< 45	1.000		1.000		1.000		1.000
≥ 45	1.601 (1.166-2.199)		1.511 (0.820-2.785)		1.809 (1.182-2.770)		1.335 (0.626-2.848)
ALP, U/L		0.058		0.017		0.220
< 140	1.000		1.000		1.000
≥ 140	1.330 (0.990-1.787)		1.979 (1.130-3.464)		1.262 (0.871-1.829)
TBIL, umol/L		0.002		0.624		< 0.001		0.152
< 235	1.000		1.000		1.000		1.000
≥ 235	1.605 (1.191-2.163)		1.099 (0.754-1.601)		2.172 (1.531-3.082)		1.551 (0.850-2.829)
Albumin, g/L		< 0.001		0.012		< 0.001		0.149
≥ 35	1.000		1.000		1.000		1.000
< 35	2.598 (1.794-3.764)		1.735 (1.130-2.662)		2.628 (1.781-3.879)		1.417 (0.883-2.274)
CRP, mg/L		0.002		0.197		0.001		0.205
< 10	1.000		1.000		1.000		1.000
≥ 10	1.599 (1.180-2.168)		1.265 (0.885-1.807)		1.797 (1.260-2.564)		1.308 (0.863-1.983)
PT, second		0.760				0.277
< 14	1.000				1.000
≥ 14	0.928 (0.574-1.499)				0.736 (0.424-1.278)

¹Any morbidity, Clavien-Dino classification grade I or higher.

²Severe morbidity, Clavien-Dino classification grade IIIa or higher.

OR: Odds ratio; CI: Confidence interval; ECOG: Eastern Cooperative Oncology Group; BMI: Body mass index; ASA: American Society of Anesthesiologists; RDW: Red blood cell distribution width; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: γ-glutamyl transferase; TBIL: Total bilirubin; CRP: C-reactive protein; PT: Prothrombin time.