Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

doi:10.4251/wjgo.v17.i1.98168

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Jan 15, 2025; 17(1): 98168
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.98168

Table 1 Baseline characteristics of patients who underwent laparoscopic pancreaticoduodenectomy, n (%)

Variables	Total (n = 804)	Red blood cell distribution width		P value
Variables	Total (n = 804)	< 15.4 (n = 573)	≥ 15.4 (n = 231)	P value
Age, years
< 65	478 (59.5)	353 (61.6)	125 (54.1)	0.050
≥ 65	326 (40.5)	220 (38.4)	106 (45.9)
Sex				0.325
Male	529 (65.8)	383 (66.8)	146 (63.2)
Female	275 (34.2)	190 (33.2)	85 (36.8)
Body mass index, kg/m²
< 25	500 (62.2)	341 (59.5)	159 (68.8)	0.014
≥ 25	304 (37.8)	232 (40.5)	72 (31.2)
Drinking				0.489
No	553 (68.8)	390 (68.1)	163 (70.6)
Yes	251 (31.2)	183 (31.9)	68 (29.4)
Smoking				0.983
No	526 (65.4)	375 (65.4)	151 (65.4)
Yes	278 (34.6)	198 (34.6)	80 (34.6)
ECOG score				0.029
0-1	734 (91.3)	531 (92.7)	203 (87.9)
2	70 (8.7)	42 (7.3)	28 (12.1)
Comorbidity
Hypertension	218 (27.1)	156 (27.2)	62 (26.8)	0.911
Pancreatitis	65 (8.1)	52 (9.1)	13 (5.6)	0.105
Diabetes mellitus	157(19.5)	119 (20.8)	38 (16.5)	0.162
Upper-abdominal operation history				0.717
No	759 (94.4)	542 (94.6)	217 (93.9)
Yes	45 (5.6)	31 (5.4)	14 (6.1)
Preoperative biliary drainage				0.009
No	682 (84.8)	498 (86.9)	184 (79.7)
Yes	122 (15.2)	75 (13.1)	47 (20.3)
Pathology				< 0.001
Malignant tumor	618 (76.9)	414 (72.3)	204 (88.3)
Benign tumor	186 (23.1)	159 (27.7)	27 (11.7)
ASA physical status				0.083
II	514 (63.9)	377 (65.8)	137 (59.3)
III	290 (36.1)	196 (34.2)	94 (40.7)
ALT, U/L, mean ± SD	134.91 ± 144.16	122.26 ± 134.32	166.31 ± 162.17	< 0.001
< 40	257 (32.0)	214 (37.3)	43 (18.6)	< 0.001
≥ 40	547 (68.0)	359 (62.7)	188 (81.4)
AST, U/L, mean ± SD	104.40 ± 134.09	92.11 ± 128.77	134.89 ± 142.22	< 0.001
< 35	549 (68.3)	349 (60.9)	31 (13.4)	< 0.001
≥ 35	255 (31.7)	224 (39.1)	200 (86.6)
ALP, U/L, mean ± SD	345.49 ± 305.36	287.75 ± 263.95	488.72 ± 351.25	< 0.001
< 140	268 (33.3)	239 (41.7)	29 (12.6)	< 0.001
≥ 140	536 (66.7)	334 (58.3)	202 (87.4)
GGT, U/L, mean ± SD	511.57 ± 559.77	115.90 ± 529.70	667.70 ± 601.57	< 0.001
< 54	217 (27.0)	195 (34.0)	22 (9.5)	< 0.001
≥ 54	587 (73.0)	378 (66.0)	209 (90.5)
TBIL, μmol/L, mean ± SD	125.95 ± 141.75	87.95 ± 109.20	220.19 ± 167.27	< 0.001
< 235.0	547 (68.0)	449 (78.4)	98 (42.4)	< 0.001
≥ 235.0	257 (32.0)	124 (21.6)	133 (57.6)
Albumin, g/L, mean ± SD	39.55 ± 5.65	40.74 ± 5.28	36.60 ± 5.47	< 0.001
< 35	152 (18.9)	60 (10.5)	92 (39.8)	< 0.001
≥ 35	652 (81.1)	513 (89.5)	139 (60.2)
CRP, mg/L, mean ± SD	12.72 ± 21.03	12.14 ± 21.65	14.14 ± 19.39	< 0.001
< 10	564 (70.1)	425 (74.2)	139 (60.2)	< 0.001
≥ 10	240 (29.9)	148 (25.8)	92 (39.8)
PT, second, mean ± SD	12.32 ± 1.39	12.26 ± 1.32	12.47 ± 1.54	0.105
< 14	730 (90.8)	523 (91.3)	207 (89.6)	0.460
≥ 14	74 (9.2)	50 (8.7)	24 (10.4)
Hemoglobin, g/L, mean ± SD	126.52 ± 18.88	131.65 ± 16.46	113.80 ± 18.49	< 0.001
< 115	192 (23.9)	79 (13.8)	113 (48.9)	< 0.001
≥ 115	612 (76.1)	494 (86.2)	118 (51.1)
Leucocytes, 10⁹/L, mean ± SD	6.37 ± 2.64	6.13 ± 2.43	6.96 ± 3.03	< 0.001
< 9.5	722 (89.8)	521 (90.9)	201 (87.0)
≥ 9.5	82 (10.2)	52 (9.1)	30 (13.0)	0.097
Lymphocyte, 10⁹/L, mean ± SD	1.55 ± 0.60	1.64 ± 0.59	1.33 ± 0.57	< 0.001
< 3.2	797 (99.1)	567 (99.0)	230 (99.6)	0.680 (F)
≥ 3.2	7 (0.9)	6 (1.0)	1 (0.4)
Platelet, 10⁹/L, mean ± SD	258.893 ± 88.76	249.92 ± 75.82	281.27 ± 111.84	< 0.001
< 350	698 (86.8)	518 (90.4)	180 (77.9)	< 0.001
≥ 350	106 (13.2)	55 (9.6)	51 (22.1)
NLR, mean ± SD	3.23 ± 2.94	2.70 ± 2.46	4.54 ± 3.56	< 0.001
PLR, mean ± SD	197.51 ± 101.20	187.46 ± 95.80	222.45 ± 109.82	< 0.001
PNI, mean ± SD	46.94 ± 6.766	48.26 ± 6.35	43.69 ± 6.64	< 0.001

ECOG: Eastern Cooperative Oncology Group; ASA: American Society of Anesthesiologists; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: γ-glutamyl transferase; TBIL: Total bilirubin; CRP: C-reactive protein; PT: Prothrombin time; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; PNI: Prognostic nutritional index.

Citation: Cao XR, Xu YL, Chai JW, Zheng K, Kong JJ, Liu J, Zheng SZ. Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy. World J Gastrointest Oncol 2025; 17(1): 98168
URL: https://www.wjgnet.com/1948-5204/full/v17/i1/98168.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i1.98168