Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

Figure 4 Interleukin-17A promoted hepatocellular carcinoma cell proliferation, migration, and angiogenesis. A: Growth curve showed that interleukin-17A (IL-17A) stimulated cell proliferation, a significant difference that was detected at 24 h after treatment; B: Flow cytometry revealed that, compared with the control, IL-17A significantly increased the proportion of cells in G2/M phase; C: IL-17A elevated cyclinD1 expression in hepatocellular carcinoma (HCC) cells; D and E: Scratch tests and Transwell assays revealed that IL-17A promoted the migration of HCC cells (× 100 magnification); F: IL-17A increased the protein expression of VEGF and MMP9 in HCC cells. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. PE: Phycoerythrin; PI: Propidium iodide.