Dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution

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Jan 15, 2025 (publication date) through Dec 23, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jan 15, 2025; 17(1): 96822
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.96822

Table 2 Prevalence of DPYD polymorphisms

DPYD variant	Number detected (%)
HapB3	2 (1.3)¹
DPYD2A	1 (0.7)¹
c.2846A>T	1 (0.7)¹
DPYD13	0 (0)
DPYD6	18 (12.1)²
Wild-type	127 (85.2)
All polymorphisms	22 (14.8)
All polymorphisms except DPYD6	4 (2.7)

¹All in heterozygosity.

²All in heterozygosity except 1 in homozygosity.

Data are n (%).

Citation: D'Amato M, Iengo G, Massa N, Carlomagno C. Dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution. World J Gastrointest Oncol 2025; 17(1): 96822
URL: https://www.wjgnet.com/1948-5204/full/v17/i1/96822.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i1.96822