Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

Table 5 Stratified analyses between rs77886248 polymorphism and esophageal squamous cell carcinoma risk by sex, age, smoking status and alcohol consumption

Variables	Control/case numbers				Adjusted OR/P value (95%CI of OR)
	TT	TA	AA	TA + AA	TT	TA	AA	TA + AA	AA vs (TA + AA)
Sex
Male	779/680	44/64	1/1	45/65	1	1.619/0.027	1.772/0.686	1.623/0.025	1.714/0.704
						(1.057-2.482)	(0.11-28.458)	(1.063-2.476)	(0.107-27.524)
Female	287/256	26/24	1/0	27/24	1	1.024/0.937		0.979/0.942
						(0.57-1.839)	-/- (-)	(0.548-1.749)	-/- (-)
Age
≥ 63	544/509	31/49	1/1	32/50	1	1.643/0.046	1.255/0.874	1.631/0.046	1.21/0.894
						(1.009-2.675)	(0.76-20.757)	(1.009-2.639)	(0.073-20.012)
< 63	522/427	39/39	1/0	40/39	1	1.158/0.559		1.134/0.616
						(0.707-1.898)	-/- (-)	(0.694-1.853)	-/- (-)
Smoking status
Ever	314/405	18/45	0/1	18/46	1	1.954/0.035	-/- (-)	2.401/0.024	-/- (-)
						(1.049-3.642)		(1.099-3.791)
Never	752/531	52/43	2/0	54/0	1	1.164/0.483	-/- (-)	1.118/0.604	-/- (-)
						(0.762-1.778)		(0.734-1.702)
Alcohol consumption
Ever	76/294	6/28	0/0	6/28	1	1.111/0.824	-/- (-)	1.111/0.824	-/- (-)
						(0.44-2.807)		(0.44-2.807)
Never	990/642	64/60	2/1	66/61	1	1.41/0.068	0.722/0.793	1.389/0.078	0.704/0.777
						(0.975-2.038)	(0.64-8.61)	(0.964-1.999)	(0.062-7.959)

OR: Odds ratio.