Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

Table 4 Stratified analyses between rs4556933 polymorphism and esophageal squamous cell carcinoma risk by sex, age, smoking status and alcohol consumption

Variables	Control/case numbers				Adjusted OR/P value (95%CI of OR)
	GG	GA	AA	GA + AA	GG	GA	AA	GA + AA	AA vs (GG + GA)
Sex
Male	399/424	351/225	74/91	425/316	1	0.587/< 0.01	1.18/0.369	0.689/0.001	1.463/0.032
						(0.464-0.742)	(0.823-1.691)	(0.555-0.855)	(1.033-2.071)
Female	151/163	136/86	27/27	163/113	1	0.57/0.02	0.898/0.718	0.624/0.005	1.156/0.614
						(0.401-0.811)	(0.502-1.607)	(0.449-0.868)	(0.658-2.032)
Age
≥ 63	290/324	241/163	45/66	286/229	1	0.588/< 0.01	1.283/0.257	0.697/0.004	1.582/0.032
						(0.449-0.769)	(0.833-1.976)	(0.543-0.893)	(1.041-2.403)
< 63	260/263	246/148	56/52	302/200	1	0.568/< 0.01	0.932/0.754	0.634/0.001	1.198/0.406
						(0.427-0.755)	(0.601-1.447)	(0.487-0.826)	(0.783-1.832)
Smoking status
Ever	151/262	152/135	29/52	181/187	1	0.485/< 0.01	1.009/0.974	0.568/0.001	1.39/0.223
						(0.344-0.683)	(0.583-1.749)	(0.412-0.782)	(0.818-2.362)
Never	399/325	335/176	72/66	407/242	1	0.645/< 0.01	1.156/0.442	0.734/0.006	1.38/0.078
						(0.509-0.817)	(0.799-1.674)	(0.59-0.914)	(0.964-1.973)
Alcohol consumption
Ever	31/190	45/92	6/38	51/130	1	0.326/< 0.01	1.019/0.969	0.407/< 0.01	1.745/0.23
						(0.192-0.552)	(0.395-2.63)	(0.246-0.674)	(0.703-4.332)
Never	519/397	442/219	95/80	537/299	1	0.646/< 0.01	1.117/0.507	0.729/0.001	1.343/0.068
						(0.524-0.797)	(0.806-1.548)	(0.601-0.885)	(0.978-1.842)

OR: Odds ratio.