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©The Author(s) 2025.
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 96702
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.96702
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.96702
Table 3 Analyses of associations between selected genotyped single nucleotide polymorphisms of activin A receptor type 1C on risk of esophageal squamous cell carcinoma
Locus | Genotype | Control | Case | Co-dominant model | Dominant model | Recessive model | Addictive model | |
OR (95%CI) | P value | OR (95%CI)/P value | OR (95%CI)/P value | OR (95%CI)/P value | ||||
rs4664229 | TT | 908 | 835 | 1 | 0.311 | 0.894 (0.721-1.107) | 1.487 (0.624-3.545) | 0.928 (0.76-1.131) |
TC | 221 | 177 | 0.871 (0.7-1.084) | 0.216 | 0.303 | 0.37 | 0.456 | |
CC | 9 | 12 | 1.45 (0.608-3.459) | 0.402 | ||||
rs4556933 | GG | 550 | 587 | 1 | < 0.001 | 0.684 (0.577-0.811) | 1.349 (1.019-1.786) | 0.848 (0.743-0.969) |
GA | 487 | 311 | 0.598 (0.498-0.719) | < 0.001 | < 0.001 | 0.036 | 0.015 | |
AA | 101 | 118 | 1.095 (0.819-1.463) | 0.541 | ||||
rs77886248 | TT | 1066 | 936 | 1 | 0.087 | 1.408 (1.019-1.944) | 0.555 (0.05-6.126) | 1.366 (0.999-1.870) |
TA | 70 | 88 | 1.432 (1.034-1.983) | 0.031 | 0.038 | 0.631 | 0.051 | |
AA | 2 | 1 | 0.569 (0.052-6.29) | 0.646 | ||||
rs77263459 | TT | 647 | 593 | 1 | 0.087 | 0.958 (0.807-1.136) | 1.169 (0.84-1.628) | 0.999 (0.870-1.147) |
TC | 417 | 354 | 0.926 (0.773-1.109) | 0.405 | 0.62 | 0.355 | 0.988 | |
CC | 74 | 77 | 1.135 (0.810-1.592) | 0.462 | ||||
rs6734630 | AA | 908 | 838 | 1 | 0.402 | 0.881 (0.711-1.092) | 1.236 (0.5-3.054) | 0.906 (0.743-1.105) |
GA | 221 | 177 | 0.868 (0.697-1.08) | 0.204 | 0.247 | 0.646 | 0.331 | |
GG | 9 | 10 | 1.204 (0.487-2.977) | 0.688 |
- Citation: Lin SY, Huang H, Yu JJ, Su F, Jiang T, Zhang SY, Lv L, Long T, Pan HW, Qi JQ, Zhou Q, Tang WF, Ding GW, Wang LM, Tan LJ, Yin J. Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population. World J Gastrointest Oncol 2025; 17(1): 96702
- URL: https://www.wjgnet.com/1948-5204/full/v17/i1/96702.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v17.i1.96702