Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report

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Jan 15, 2025 (publication date) through Jan 23, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jan 15, 2025; 17(1): 100757
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.100757

Table 2 Key regulated factor of neuroendocrine carcinoma of gallbladder-related genes

	Key TF	Description	Overlapped genes	P value	FDR
1	YY1	YY1 transcription factor	APC, GNAS, TP53	1.74E-05	1.32E-04
2	KAT2B	K(lysine) acetyltransferase 2B	RB1, SMAD4	2.40E-05	1.32E-04
3	PAX5	Paired box 5	RB1, TP53	6.45E-05	2.36E-04
4	DNMT1	DNA (cytosine-5-)-methyltransferase 1	RB1, TP53	1.42E-04	3.91E-04
5	EZH2	Enhancer of zeste homolog 2 (Drosophila)	APC, TP53	2.38E-04	5.24E-04
6	FOS	FBJ murine osteosarcoma viral oncogene homolog	SMAD4, TP53	4.85E-04	7.61E-04
7	GATA1	GATA binding protein 1 (globin transcription factor 1)	GATA1, GNAS	4.85E-04	7.61E-04
8	SPI1	SFFV proviral integration oncogene spi1	BTK, GATA1	5.73E-04	7.88E-04
9	MYC	V-myc myelocytomatosis viral oncogene homolog (avian)	GATA1, TP53	1.48E-03	1.81E-03
10	E2F1	E2F transcription factor 1	RB1, TP53	2.64E-03	2.90E-03
11	TP53	Tumor protein p53	RB1, TP53	3.92E-03	3.92E-03

TF: Transcription factor; FDR: False discovery rate; SFFV: Spleen focus forming virus.

Citation: Yang YC, Chen ZT, Wan DL, Tang H, Liu ML. Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report. World J Gastrointest Oncol 2025; 17(1): 100757
URL: https://www.wjgnet.com/1948-5204/full/v17/i1/100757.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i1.100757