Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report

Table 1 The information of neuroendocrine carcinoma of gallbladder-related mutated genes

Genes	Original name	Cytoband	Exon count	Variant type	Abundance variation
APC	APC regulator of WNT signaling pathway	5q22.2	20	Copy number variation	CN: 1.2
ARID2	AT-rich interaction domain 2	12q12	22	c.3382C>T (p.Q1128)	77.3%
IFNA6	interferon alpha 6	9p21.3	1	c.53C>G (p.S18)	42.8%
KEAP1	Kelch like ECH associated protein 1	19p13.2	7	c.1408C>T (p.R470C)	87.9%
RB1	RB transcriptional corepressor 1	13q14.2	27	c.772-776del (p.N258Efs1)	76.1%
SMAD4	SMAD family member 4	18q21.2	12	Copy number variation	CN: 1.1
TP53	tumor protein p53	17p13.1	11	Copy number variation	CN: 1.1
				c.574C>T (p.Q192)	81.3%
BTK	Bruton tyrosine kinase	Xq22.1	21	c.574C>T (p.D232V)	48.6%
GATA1	GATA binding protein 1	Xp11.23	6	c.173C>A (p.A58E)	42.5%
GNAS	GNAS complex locus	20q13.32	22	c.1048G>C (p.E350Q)	42.9%
MECOM	MDS1 and EVI1 complex locus	3q26.2	24	c.1161G>T (p.Q387H)	2.4%