Human bone marrow mesenchymal stem cell-derived exosomes loaded with gemcitabine inhibit pancreatic cancer cell proliferation by enhancing apoptosis

Figure 3 Exosomes loaded with gemcitabine enhances the frequency of gemcitabine-induced apoptotic pancreatic cancer cells. A and B: Panc-1 (A) and MiaPaca-2 (B) cells were treated in triplicate with various concentrations of gemcitabine or exosomes loaded with gemcitabine for 72 hours, and the frequency of apoptotic cells was determined by flow cytometry. Data are represented as the mean ± SD (n = 3) of a representative experiment. ^bP < 0.01, vs the gemcitabine group; ^cP < 0.001, vs the gemcitabine group; ns: No significance. EXO: Exosomes; GEM: Gemcitabine; EXO-GEM: Exosomes loaded with gemcitabine.